Tech Note: Isolation of Mouse Skin Cells with the Singulator™ Platform

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The skin is the outermost protective barrier organism and comprises of two main layers, the epidermis and the dermis. To understand skin homeostasis in healthy and diseased states, a thorough molecular characterization of every type of skin cell type is required. This in turn requires isolation of viable cells from skin for downstream genomics and cell biology analyses. However, traditional methods for isolating cells from skin tissue, are time-consuming, complex, and technically challenging. Here, we demonstrate the use of the SingulatorTM 100 for isolation of viable mouse skin cells with high yield with S2 Genomics’ Skin Cell Reagent.